Without “Cherry-picking,” the numbers return to estimates established by previous scientists

Cherry-picking the most aggressive of three presented ratios, gooses the key denominator before calculation.  The Authors’ and other scientists’ data presented in this selfsame report, averaged, return prevalence to normal.

To calculate the prevalence of 1:217, the authors’ blended both FH and FDB and then used a divisor of .387 to calculate in the remainder of the spectrum.  But in their report they also included spectrum detail from two other science teams, Damgaard, et al, and Brusgaard, et al.[1]   If we wish to avoid cherry-picking, we should average all three results.  Also, if we want to calculate FH LDLR alone, to avoid conflating FH and FDB, then we take out FDB. Now our average divisor is .3362.

Without cherry picking FH prevalence matches the traditional estimate

Cherry-picking the most extreme of the three presented ratios, leverages the denominator before calculation. Without leveraging or linguistic conflation, we return to an FH LDLR prevalence slightly lower than the established 1 in 500.


[1] 2nd Report, Supplementary Table 2.