Just as we saw with goosing the number of birds, we shall see that the FDB prevalence leverage is extreme. With inflation, the prevalence is 1:118. Without inflation, the prevalence is 1:884. This is because there is no “proportion” of a spectrum to speak of, since the R3500Q/W make up the whole of the FDB spectrum found in the studies. Below, following the same procedure, here are calculations of APOB with and without LDLR added into the denominators – see the next page for screenshots of raw data.
In the table below, on the left we correctly isolate APOB to calculate APOB; on the right, we put LDLR in the denominator.
When we calculate the fraction of the spectrum, we are really asking, How many other APOB are there? And we don’t have a right to the question, because we already have all the APOB from the beginning. There are no others. 19 is not half of an amulet, from which we can derive another half. 19 is the whole amulet: 19 probands ÷ the proband total of 19 = 1. And so 111 APOB molecular hits in the Copenhagen sample ÷ 1 = 111 APOB total mutation carriers in the Copenhagen sample.
2nd report’s Supplement, Tables 2 and 3: Goosing FDB APOB with FH LDLR
Screenshot overlay: I’ve added the pointers and emphases.