In the image below, on the left: in 2003, LDLR, APOB, and PCSK9 were considered Autosomal Dominant [Hypercholesterolemia] (ADH). FH is a subset. On the right, in 2016, the same three are called, “FH.” FH is now the whole set. In both papers, of course, FH-as-LDLR is the same 1:500. The different “FH” numbers between the two studies is due to linguistics, not epidemiology. Those who are working with FH are now declaring that Goldstein and Brown’s epidemiological estimates are obsolete and incorrect. In their stead we find linguistics. How do the Nobel Prize winners take this? It’s hard to say. Nobel Prize winners Goldstein and Brown have been Regeneron directors for years now. One of the authors on the Regeneron report, George Yancopoulos, is listed in Regeneron’s 10-K as President, Chief Science Officer and Director. However, one thing is not in doubt: the integrity of the scientific record has been compromised.